GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9309473 | 1 | rs6740223 | chr2:73653332 | ALMS1P | chr2:73872046-73912692:+ | 0.38 | 5.71 | 2.23E-8 | Metabolite levels |
| BLCA | cis | rs4663866 | 1 | rs6741269 | chr2:239179418 | LOC151174 | chr2:239133754-239140318:- | 0.46 | 4.5 | 9.06E-6 | Irritable bowel syndrome |
| BLCA | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | AHSA2 | chr2:61404553-61414058:+ | -0.19 | -5.04 | 7.34E-7 | Tuberculosis |
| BLCA | cis | rs6545883 | 1 | rs6742276 | chr2:61768745 | C2orf74 | chr2:61372243-61391964:+ | 0.37 | 6.05 | 3.53E-9 | Tuberculosis |
| BLCA | cis | rs9371538 | 1 | rs67445790 | chr6:151876730 | C6orf97 | chr6:151815175-151942327:+ | 0.27 | 3.89 | 0.000116 | Bone mineral density (spine) |
| BLCA | cis | rs17108533 | 1 | rs67446674 | chr14:71217852 | MAP3K9 | chr14:71194856-71275888:- | 0.44 | 4.25 | 2.73E-5 | Response to antipsychotic treatment in schizophrenia (reasoning) |
| BLCA | cis | rs9309473 | 1 | rs6745368 | chr2:73809974 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.12 | 4.75E-7 | Metabolite levels |
| BLCA | cis | rs6547741 | 1 | rs6749052 | chr2:27772879 | C2orf16 | chr2:27799389-27805588:+ | 0.22 | 3.83 | 0.000152 | Oral cavity cancer |
| BLCA | cis | rs6547741 | 1 | rs6750943 | chr2:27777904 | C2orf16 | chr2:27799389-27805588:+ | 0.23 | 3.97 | 8.5E-5 | Oral cavity cancer |
| BLCA | cis | rs9309473 | 1 | rs6753344 | chr2:73653138 | ALMS1P | chr2:73872046-73912692:+ | -0.33 | -4.96 | 1.05E-6 | Metabolite levels |
| BLCA | cis | rs2243480 | 1 | rs67536397 | chr7:65947917 | CCT6P1 | chr7:65216092-65228661:+ | 0.36 | 4.72 | 3.38E-6 | Diabetic kidney disease |
| BLCA | cis | rs9309473 | 1 | rs6755217 | chr2:73641285 | ALMS1P | chr2:73872046-73912692:+ | 0.32 | 4.57 | 6.57E-6 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs6755241 | chr2:73641364 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.78 | 2.53E-6 | Metabolite levels |
| BLCA | cis | rs9309473 | 1 | rs6756987 | chr2:73687077 | ALMS1P | chr2:73872046-73912692:+ | 0.39 | 5.82 | 1.23E-8 | Metabolite levels |
| BLCA | cis | rs6759004 | 1 | rs6759004 | chr2:202004676 | CFLAR | chr2:201980816-202029001:+ | -0.27 | -4.85 | 1.8E-6 | Triptolide cytotoxicity |